Présence de deux épitopes différents sur la β2-microglobuline humaine définis par des anticorps monoclonaux

Two monoclonal antibodies recognizing monomorphic determinants on class I antigens of MHC were characterized. They were shown to recognize β2m by cytotoxicity inhibition studies. The epitopes recognized were different, as assayed by cross-inhibition and phylogenetical studies. One antibody recognized free as well as HLA-associated β2m. The other reacted with a conformational epitope which was well conserved during evolution.