Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern
Bioorganic & Medicinal Chemistry Letters（2010）
摘要
Compound 11 showed >∼840-fold CB1/CB2 subtype selectivity whereas 6 was only 31-fold selective.
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关键词
Cannabinoid CB1 receptor,Site of metabolism prediction,Metasite,Rimonabant,Subtype selectivity,Polar surface area,Lipophilicity,P-Glycoprotein
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