Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists

Aimee L. Crombie,Thomas M. Antrilli,Brandon A. Campbell,David L. Crandall,Amedeo A. Failli,Yanan He,Jeffrey C. Kern,William J. Moore,Lisa M. Nogle,Eugene J. Trybulski

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A series of biaryl amides containing an azabicyclo[3.2.1]octane amine headpiece were synthesized and evaluated as mixed arginine vasopressin (AVP) receptor antagonists.

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关键词

Azabicyclo[3.2.1]octane,Vasopressin,V1a-receptor antagonist,V2-receptor antagonist

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