Baroreflex Sensitivity In Rabbits During The Development Of Experimental Renal-Hypertension And Medial Sclerosis
CLINICAL AND EXPERIMENTAL HYPERTENSION(1980)
摘要
Baroreflex sensitivity was assessed in 9 normotensive (N), 8 renal wrap (one kidney model, RH) and 16 medial sclerotic rabbits (MS, fed on calciferol 50,000 i.u. and calcium lactate 1g for 10 days) before (mean 8P;N, 79±3.3 mm Hg; RH, 80±7.4 mm Hg; and MS, 83±1.0 mm Hg) and at monthly intervals for up to 16 weeks after the induction of the disease processes (mean 8P;N, 87±3.9 mm Hg; RH, 127±7.2 mm Hg and MS, 99±3.8 mm Hg). Blood pressure was elevated by i.v. phenylephrine (5 and 10 μg.kg−1) or angiotensin (250 ng.kg−1) and baroreflex sensitivity assessed by the increase of pulse interval per unit rise of pressure. The pressor response was greater in the RH and MS than in the N rabbits. The baroreflex sensitivity showed a progressive reduction with time and with the elevation of blood pressure in both MS and RH rabbits. The difference was significantly greater (P 0.05). There was an inverse relationship between baroreflex sensitivity and the pressor respons...
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