Antimicrobial Activities Of Twenty Lysine-Peptoid Hybrids Against Clinically Relevant Bacteria And Fungi
CHEMOTHERAPY(2008)
摘要
Background: This paper describes the antimicrobial activities of 20 lysine-peptoid hybrids against a selection of clinically relevant bacteria and fungi. Methods: Minimal inhibitory concentrations were determined against methicillin-susceptible Staphylococcus aureus (ATCC 29213), methicillin-resistant S. aureus (ATCC 33591), vancomycin-intermediate S. aureus (ATCC 700699 MU50), vancomycin-resistant Enterococcus faecium (ATCC 700221), Pseudomonas aeruginosa (ATCC 27853), Salmonella typhimurium (clinical isolate), Klebsiella pneumoniae (clinical isolate), amphotericin-B-resistant C. albicans (ATCC 200955) and Cryptococcus neoformans (clinical isolate). Results: The lysine-peptoid hybrids proved to be active against all strains tested, except K. pneumoniae. For each susceptible strain, we identified at least 4 lysine-peptoid hybrids showing excellent activity. The most active compounds displayed minimal inhibitory concentrations ranging from <= 1.6 to 6.25 mu M. Conclusion: This study demonstrates that lysine-peptoid hybrids show activity against drug-resistant pathogens. Copyright (c) 2008 S. Karger AG, Basel.
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关键词
antibacterial activity, antimicrobial agents, Candida albicans, lysine-peptoid hybrids, methicillin-resistant Staphylococcus aureus, minimal inhibitory concentration
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