In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Marc Vermeir,Alex Hemeryck,Filip Cuyckens,Andres Francesch,Marc Bockx,Jos Van Houdt,Kathleen Steemans,Geert Mannens,Pablo Avilés,Roland De Coster

Biochemical Pharmacology（2009）

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摘要

The in vitro metabolism of 14C-trabectedin is qualitatively similar in monkey and man. Biotransformation occurs predominantly at its A subunit. At clinically relevant levels, CYP3A4 is the main CYP involved.

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关键词

Trabectedin,In vitro metabolism,Human,Monkey,CYP reaction phenotyping

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