Age at natural menopause is not linked with the follicle-stimulating hormone receptor region: a sib-pair study
Fertility and Sterility(2004)
摘要
Conclusion(s) Possibly, age at natural menopause in the more or less normal range is not part of the spectrum of phenotypes determined by mutations in the FSH-receptor gene. Alternatively, our results might be explained by genetic heterogeneity in the left tail of the distribution of menopausal age. This can limit the chance of finding a genetic locus, especially if this factor has a modest contribution to the phenotype.
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关键词
FSH-receptor,age at menopause,early menopause,sib-pair study,linkage
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