Effects of Wenxinkeli on the Ultrastructure of Vascular Endothelia Cells in Rats with Myocardial Infarction

Objective To observe the effects of Wenxinkeli on the ultrastructure of vascular endothelia cells in rats with myocardial infarction(MI).Methods 30 SD rats were divided randomly into control group(n=10),MI group(n=10) and MI + Wenxinkeli group(n=10).The contents of nitric oxide(NO) and endothelin-1(ET-1) were detected in plasma of rats.The ultrastructure of vascular endothelia cells was observed by electron microscope.Results Compared with control group,the content of NO significantly decreased(P 0.01) and the content of ET-1 significantly increased(P 0.01) in MI group,mitochondria swelled,sarcoplasmic reticulums were expanded and endothelia shed.Compared with MI group,the content of NO significantly increased(P 0.01) and the content of ET-1 significantly decreased(P 0.01) in MI + Wenxinkeli group,mitochondria swelled,sarcoplasmic reticulums were expanded and no endothelia shed.Conclusion Wenxinkeli can ameliorate the ultrastructure of vascular endothelia cells in rats with myocardial infarction,which is related with the changes of NO and ET-1 contents.