Predicting changes in clinical status of young asthmatics: Clinical scores or objective parameters?
PEDIATRIC PULMONOLOGY(2009)
摘要
Preventing asthma exacerbation is an important goal of asthma management. The existing clinical tools are not good in predicting asthma exacerbations in young children. Childhood Asthma Control Test (C-ACT) was recently published to be a simple tool for assessing disease control in young children. This study investigated C-ACT and other disease-related factors for indicating longitudinal changes in asthma status and predicting asthma exacerbations. During the same clinic visit, asthma patients aged 4-11 years completed the Chinese version of C-ACT and underwent exhaled nitric oxide and spirometric measurements. Blinded to these results, the same investigator assigned Disease Severity Score (DSS) and rated asthma control according to Global Initiative for Asthma. Asthma exacerbations during the next 6 months were recorded. Ninety-seven patients were recruited, with their mean (standard deviation [SD]) age being 9.2 (2.0) years. Thirty-six (37.1%) patients had uncontrolled asthma at baseline. C-ACT DSS, and FEV1 differed among patients with different control status (P < 0.001 for C-ACT and DSS; P=0.028 for FEV1). Thirty-two patients had asthma exacerbations during the 6-month follow-up. Changes in patients' C-ACT scores correlated with changes in asthma control status, DSS, and FEV1 (P=0.019, 0.034, and 0.020, respectively). C-ACT score was lower among patients with asthma exacerbations (mean [SD]: 22.9 [4.2] vs. 24.5 [2.1]; P=0.015). Logistic regression confirmed that the occurrence of asthma exacerbations was associated only with baseline C-ACT (B=-0.203, P=0.042). In conclusion, C-ACT is better than DSS and objective parameters in reflecting changes in asthma status and predicting asthma exacerbations in young children. Pediatr Pulmonol. 2009; 44:442-449. (C) 2009 Wiley-Liss, Inc.
更多查看译文
关键词
asthma,childhood asthma control test,exacerbation,prediction
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络