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Carboxylate bioisosteres of pregabalin

Jacob B. Schwarz,Norman L. Colbry,Zhijian Zhu,Brian Nichelson,Nancy S. Barta,Kristin Lin,Raymond A. Hudack,Sian E. Gibbons,Paul Galatsis,Russell J. DeOrazio,David D. Manning,Mark G. Vartanian,Jack J. Kinsora,Susan M. Lotarski,Zheng Li,Melvin R. Dickerson,Ayman El-Kattan,Andrew J. Thorpe,Sean D. Donevan,Charles P. Taylor,David J. Wustrow

Bioorganic & Medicinal Chemistry Letters（2006）

引用 17|浏览64
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摘要
Truncation and acid replacement with tetrazole furnished a compound with a similar pattern of activity to pregabalin.
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关键词
Gabapentin,Pregabalin,α2–δ Subunit,Tetrazole
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