P4 cap modified tetrapeptidyl α-ketoamides as potent HCV NS3 protease inhibitors

David X Sun,Lifei Liu,Beverly Heinz,Alexander Kolykhalov,Jason Lamar,Robert B Johnson,Q.May Wang,Yvonne Yip,Shu-Hui Chen

Bioorganic & Medicinal Chemistry Letters（2004）

引用 34|浏览16

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摘要

The design, syntheses, and biological evaluation of new series of P4 tetrazole, adipic acid, ester, amide capped tetrapeptidyl α-ketoamide based HCV NS3 protease inhibitors are discussed.

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