Clarithromycin-Induced Eosinophilic Pneumonia
INTERNAL MEDICINE(2004)
摘要
Clarithromycin (CAM) has been widely used for the treatment of respiratory infection. Macrolides are generally well tolerated and their adverse reactions are rare. An 80-year-old woman with nontuberculous mycobacterium infection was treated with combined chemotherapy, including isoniazid, rifampicin, and ethambutol. She developed a fever and peripheral blood eosinophilia, and new subpleural consolidations were observed on chest radiography three days after add-on therapy with CAM. The symptoms and clinical findings improved with the withdrawal of CAM. Histopathologic examinations confirmed the diagnosis of eosinophilic pneumonia. This is the first report of CAM-induced eosinophilic pneumonia.
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关键词
drug-induced pneumonitis, eosinophilia, macrolides, eosinophilic cationic protein, interleukin-5, nontuberculous mycobacterium infection
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