Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

J.M. Elliott,M.A. Cascieri,G. Chicchi,S. Davies,F.J. Kelleher,M. Kurtz,T. Ladduwahetty,R.T. Lewis,A.M. MacLeod,K.J. Merchant,S. Sadowski,G.I. Stevenson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

A series of novel serine derived NK, antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding. (C) 1998 Elsevier Science Ltd. All rights reserved.

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nk1 antagonists,serine substituents

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