[Endophytic fungi from Ginkgo biloba and their biological activities].

OBJECTIVE:To research the isolation method, identification and screen for bioactivities endophytic fungi from ginkgo. METHOD:Endophytic fungi from ginkgo were separated. By means of microdilution method, activities of endophytes against pathogenic fungi were tested. Then, using DPPH, the antioxidant activities were measured. RESULT:Nine strains (16.1%) showed antifungal activities against Candida albicans, Cryptococcus neoformans, Trichophyton rubrum and Aspergillus fumigatus. Among these bioactive strains, the growth of T. rubrum was strongly inhibited by T-1-2-1, as the MIC80 was equal to fluconazole, the positive control. Five strains (8.9%) showed antioxidant activities. Among them sample T-3-2-2 and T-6-5-7 showed the strongest antioxidant activities. CONCLUSION:Endophytic fungi of ginkgo would be potential and rich resources for drug development.