Pathobiology of henipavirus entry: insights into therapeutic strategies

The recently emerged paramyxoviruses, Nipah (NiV) and Hendra (HeV), designated as Biosafety Level 4 pathogens, can cause lethal respiratory and neurological disease in both animals and humans. NiV outbreaks have been associated with efficient transmission amongst livestock (pigs) and mortality rates exceeding 70%, with documented cases of human-to-human transmission. Without vaccines or effective therapeutics, NiV and HeV continue to present an impending threat to global health and economies. The current understanding of henipavirus pathobiology has led to the development of small animal models reflecting certain aspects of the human pathology. In this review, we discuss how these animal models have been critical in testing vaccination strategies and in eliciting neutralizing antibodies against the envelope glycoproteins. Additionally, the discovery of the viral receptor and development of pseudotyped-viral systems have allowed us to explore the multiple opportunities for therapeutic intervention existing within the individual steps of the henipavirus entry pathway. Current research shows promise for the future development of effective strategies to limit the impact of these biological threats.