Hyperfractionated Radiation Therapy plus Chemotherapy in Locally Advanced Cervical Cancer: Results of Two Phase I Dose- Escalation Gynecologic Oncology Group Trials

Objective. The aims of this study were to assess the early and late toxicities of multiple-daily-fraction whole pelvic radiation plus concurrent chemotherapy with either hydroxyurea or 5-fluorouracil (5-FU)/cisplatin and to determine the maximum tolerated external radiation dose in conjunction with brachytherapy, when given with either of these drug regimens, as treatment for locally advanced carcinoma of the cervix.