Amide-based inhibitors of p38alpha MAP kinase. Part 2: design, synthesis and SAR of potent N-pyrimidyl amides.

Richland Tester,Xuefei Tan,Gregory R Luedtke,Imad Nashashibi,Kurt Schinzel,Weiling Liang,Joon Jung,Sundeep Dugar,Albert Liclican,Jocelyn Tabora,Daniel E Levy,Steven Do

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Identification and optimization of a new class of N-pyrimidyl amide based p38α MAP kinase inhibitors is described. The lead structure was derived from a previously reported class of pyridine-based amides. p38α activity (enzymatic/cellular) and CYP3A4 data for the new series are presented.

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关键词

p38,MAP,Kinase,Antiinflammatory

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