Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice

Peter J Voshol,Nynke R Koopen,J.Marleen L de Vree,Rick Havinga,Hans M.G Princen,Ronald P.J Oude Elferink,Albert K Groen,Folkert Kuipers

Journal of Hepatology（2001）

引用 7|浏览6

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摘要

Background/Aims: Mdr2 P-glycoprotein deficiency in mice (Mdr2(−/−)) leads to formation of cholesterol/cholesterol-depleted bile and reduced plasma HDL cholesterol. We addressed the questions: (1) does HDL in Mdr2(−/−) mice normalize upon phospholipid and/or cholesterol feeding, and (2): is the Mdr2(−/−) liver capable of handling excess dietary cholesterol.

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关键词

High density lipoprotein,Phospholipids,Bile salts,Bilirubin,Transgenic mice

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