Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction.

Marcel Holzer,Sigrid Ziegler,Bernd Kronenberger,Christian D Klein,Rolf W Hartmann

The open medicinal chemistry journal（2008）

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摘要

Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL-HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.

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关键词

CD81-receptor,Hepatitis C virus,benzyl salicylate,large extracellular loop,microwave assisted amide syntheses,protein-protein interaction.

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