The neuropathological basis of clinical progression in multiple sclerosis
Acta neuropathologica, Volume 122, Issue 2, 2011, Pages 155-170.
demyelination remyelination axon loss neurodegeneration inflammation clinical progression
Multiple sclerosis is the major inflammatory condition affecting the central nervous system (CNS) and is characterised by disseminated focal immune-mediated demyelination. Demyelination is accompanied by variable axonal damage and loss and reactive gliosis. It is this pathology that is thought to be responsible for the clinical relapses t...更多