The neuropathological basis of clinical progression in multiple sclerosis

    Acta neuropathologica, Volume 122, Issue 2, 2011, Pages 155-170.

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    demyelination remyelination axon loss neurodegeneration inflammation clinical progression

    摘要

    Multiple sclerosis is the major inflammatory condition affecting the central nervous system (CNS) and is characterised by disseminated focal immune-mediated demyelination. Demyelination is accompanied by variable axonal damage and loss and reactive gliosis. It is this pathology that is thought to be responsible for the clinical relapses t...更多

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