Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups—new classes of PPAR γ/δ and PPAR α/γ/δ agonists

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands. Modification of the substituents on the linker and the heterocycle tail group modulated the selectivity at the different receptor subtypes.

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关键词

PPAR agonist,Indanyl acetic acid,Diabetes,Cardiovascular,Triglycerides,HDL,Cholesterol,SAR

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