Novel Coa-Polyamine Conjugates For Effective Inhibition Of Spermine/Spermidine-N-1-Acetyltransferase

Alina Simonian,Alex Khomutov,Tapani Hyvonen,Nikolay Grigorenko,Tuomo Keinanen,Jouko Vepsalainen,Leena Alhonen,Juhani Janne

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2007）

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摘要

New mimics of the transition state of spermine/spermidine-N-1 -acetyltransferase reaction were prepared starting from aminooxy analogues of spermidine or spermine and SH-CoA. The activity depended on the structure of polyamine fragment of the conjugate and best of the synthesized compounds were active at micromolar concentrations.

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关键词

polyamines, coenzyme A, SSAT, coenzyme-substrate inhibitors

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