Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1997)
摘要
Mono and bis double ester prodrugs of aminomethyl THF 1 beta-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity. (C) 1997 Elsevier Science Ltd.
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