Effects of gastrokinetic agents on human sphincter of Oddi motility

AIM:To observe the effects of domperidone,mosapride and tegaserod on the motility of human sphincter of Oddi(SO) and to analyze potential mechanisms involved.METHODS:Thirty-two patients with T-tube drainage after choledochotomy were randomly divided into three groups:domperidone group,mosapride group and tegaserod group.The pressure of the SO was measured with a choledochofiberscope via T-tube fistula.Agents were given sublingually.Basic pressure of the SO(SOBP),amplitude of the SO(SOCA),duration of phasic contractions(SOD),duodenal pressure(DP),and common bile duct pressure(CBDP)were recorded and analyzed.RESULTS:SOBP and SOCA decreased markedly not only in the domperidone group(10.30 ± 4.99 vs 6.40 ± 3.66;110.52 ± 37.80 vs 68.67 ± 41.02;both P < 0.05) but also in the mosapride group(2.56 ± 13.02 vs 6.00 ± 5.74;83.44 ± 46.16 vs 52.48 ± 44.19;both P < 0.05).SOBP and SOCA did not change after tegaserod intake.No significant changes in SOF,SOD and CBDP were noted in all the groups.CONCLUSION:Both domperidone and mosapride at clinical doses decrease SOBP and SOCA and inhibit SO motility,while tegaserod at clinical dose does not affect SO motility.