C-Alkyl 5-Membered Ring Imino Sugars As New Potent Cytotoxic Glucosylceramide Synthase Inhibitors

Vanessa Faugeroux,Yves Génisson,Nathalie Andrieu-Abadie,Sandra Colié,Thierry Levade,Michel Baltas

ORGANIC & BIOMOLECULAR CHEMISTRY（2006）

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摘要

The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.

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