2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.

Bioorganic & Medicinal Chemistry Letters(2010)

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摘要
Biaryl amides were discovered as novel and subtype selective M1 agonists. The identification, synthesis, and initial SAR that led to the discovery of compound 3j are described.
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关键词
Subtype selective M1 muscarinic acetylcholine receptor agonist,Novel M1 agonists,2′ Biaryl amides
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