A one-pot synthesis of 3-substituted-5-carbonylmethyl-1,2,4-oxadiazoles from β-keto esters and amidoximes under solvent-free conditions
Tetrahedron Letters(2007)
摘要
Herein we report a high yielding one-pot ‘green’ synthesis of 3-substituted-5-carbonylmethyl-1,2,4-oxadiazoles from readily available β-keto esters and amidoximes under simple and convenient solvent-free conditions. No additional base is needed. The reaction likely goes through an acyl ketene intermediate.
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