A practical formal synthesis of camptothecin

Subhash P. Chavan,Ashok B. Pathak,Uttam R. Kalkote

Tetrahedron Letters（2007）

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摘要

The synthesis of the DE ring of camptothecin using simple and inexpensive starting materials, employing an addition elimination reaction and selective esterification of an aliphatic carboxylic acid as key steps is described.

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关键词

Natural product,Alkaloid,Camptothecin,Anticancer

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