Ligand-gated channels.
IEEE transactions on nanobioscience（2005）
摘要
Ligand-gated ion channels (LGICs) are fast-responding channels in which the receptor, which binds the activating molecule (the ligand), and the ion channel are part of the same nanomolecular protein complex. This paper will describe the properties and functions of the nicotinic acetylcholine LGIC superfamily, which plays a critical role in the fast chemical transmission of electrical signals between nerve cells and between nerve and muscle cells. The superfamily will mainly be exemplified by the excitatory nicotinic acetylcholine receptor (nAChR) and the inhibitory glycine receptor (GlyR) channels.
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关键词
gaba a receptor,ion channels,muscle,membrane potentials,protein complex,transmembrane segment,molecular biophysics,neurophysiology,muscle cell,structure activity relationship,signal transduction,ion channel,muscle cells,protein conformation,proteins,ligand gated ion channel,synaptic transmission,glycine receptor,electrical signals,acetylcholine receptor
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