Structure-Activity Relationship At The Proximal Phenyl Group In A Series Of Non-Peptidyl N-Type Calcium Channel Antagonists

Tr Ryder,Ly Hu,Mf Rafferty,Sm Lotarski,Dm Rock, Sj Stoehr,Cp Taylor,Ml Weber, Gp Miljanich,E Millerman,Bg Szoke

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（1999）

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摘要

Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers, (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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