Wandering In The Gardens Of The Mind: Peter Mitchell And The Making Of Glynn

Peter Mitchell was an outstanding theoretical biologist who had what Leslie Orgel has characterized as a counterintuitive idea that led to a fundamental shift in the way that biochemists viewed energy metabolism. The story of the gradual replacement of the chemical hypothesis of energy transduction, which involved a non-phosphorylated high-energy intermediate (not a phosphate compound, as stated in this book), with the chemiosmotic theory has become, for historians of science, a classic example of how a paradigm shift occurs.