The Sequence Alignment/Map format and SAMtools.

Li Heng,Handsaker Bob,Wysoker Alec,Fennell Tim,Ruan Jue,Homer Nils,Marth Gabor,Abecasis Goncalo,Durbin Richard, Null Null

BIOINFORMATICS（2009）

引用 50970|浏览4

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摘要

The Sequence Alignment/Map (SAM) format is a generic alignment format for storing read alignments against reference sequences, supporting short and long reads (up to 128 Mbp) produced by different sequencing platforms. It is flexible in style, compact in size, efficient in random access and is the format in which alignments from the 1000 Genomes Project are released. SAMtools implements various utilities for post-processing alignments in the SAM format, such as indexing, variant caller and alignment viewer, and thus provides universal tools for processing read alignments.http://samtools.sourceforge.net.

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关键词

universal tool,different sequencing platform,sequence alignment,reference sequence,map format,post-processing alignment,random access,generic alignment format,alignment viewer,sam format,genomes project,indexation,sequence analysis,genome,genomics,computational biology,algorithms

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