Considerations in Making Microarray Cross-Platform Correlations

Manohar Kollegal,Sudeshna Adak,Richard Shippy,Timothy Sendera

CSBW '05 Proceedings of the 2005 IEEE Computational Systems Bioinformatics Conference - Workshops（2005）

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摘要

Comparison and integration of expression data derived from diverse microarray platforms is challenging. Factors affecting cross-platform comparison of microarray data include the choice of normalization method used, annotation differences, presence of splice variants, RNA degradation and probe distance from 3驴 end. A thorough evaluation of two commercial microarray platforms to determine an appropriate methodology for making cross-platform correlations is described here.

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关键词

microarray cross-platform correlations,normalization method,appropriate methodology,cross-platform comparison,commercial microarray platform,diverse microarray platform,expression data,annotation difference,rna degradation,cross-platform correlation,microarray data,molecular biophysics,data integrity,macromolecules,splice variant

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