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Dr. Zvi Kelman’s research is focused on developing tools and reagents for the labeling of biomolecules with stable isotopes to support biophysical and bioanalytical measurements. The NIST Biomolecular Labeling Laboratory (BL2) also provides support to external users through a proposal process. The laboratory has the equipment and reagents necessary for production, purification, and characterization of labeled proteins and other biomolecules, including peptides and nucleic acids. A part of these efforts includes the labeling of monoclonal antibodies (mAbs). mAbs are commonly developed by the pharmaceutical industry as drugs to fight a large variety of diseases, including cancer and autoimmune disease. Some structural studies on mAbs will benefit from the ability to label the antibodies with stable isotopes. The lab is developing tools and reagents for bacteria, yeast, plant and mammalian cell expression and purification of labeled mAbs.
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PROTEIN ENGINEERING DESIGN & SELECTIONno. 12 (2023)
EPJ Web of Conferences (2023): 01003
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Journal of biomolecular structure & dynamicspp.1-9, (2023)
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Epj Web of Conferences (2023): 01003-01003
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