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Our long-term goal is to identify means to ameliorate age-related muscle deterioration (sarcopenia) and combat muscle wasting in muscular dystrophy. Sarcopenia is characterized by a decline in mass, strength, and endurance of skeletal muscles, and by fat accumulation between and within myofibers. Subtle muscle injuries that occur during routine muscle activity raise a continuous demand for functional myofiber repair throughout life. However, myogenic stem cell performance declines in old age and this decline can be a contributory factor to sarcopenia. We investigate satellite cells, classically defined tissue specific myogenic stem cells that reside beneath the myofiber basal lamina, as well as non-myogenic progenitors associated with the microvasculature that may contribute to myogenesis by myogenic reprogramming. Our research approach is based on the view that muscle aging is not an isolated event that starts late in life, but rather a continuum of ongoing developmental biology processes that progress with life.
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论文共 51 篇作者统计合作学者相似作者
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Zipora Yablonka-Reuveni,Frank Stockdale,Uri Nudel,David Israeli,Helen M Blau,Asher Shainberg,Sara Neuman,Gania Kessler-Icekson, Erica Meghid Krull,Bruce Paterson, Ora Saxel Fuchs,David Greenberg,
Function (Oxford, England)no. 2 (2020)
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