基本信息
浏览量:7
职业迁徙
个人简介
With primary interests in the mechanisms of immune regulation in cancer, my research team has made seminal contributions to understanding the immunological properties of heat shock proteins in cancer immunotherapy and immune tolerance. We provided the first genetic evidence linking the heat shock response to antigen cross-presentation and adaptive immunity; pioneered the use of autologous, tumor-derived HSP70-peptide complex for the immunotherapy of leukemia; and discovered that gp96, a paralog in the endoplasmic reticulum, is the master molecular chaperone for Toll-like receptors (TLRs).
I am internationally recognized as a leader in the field of gp96 biology due to a number of contributions such as the discovery of its ATPase activity, peptide-binding properties and client-binding domain. My current research interests focus on developing better immunotherapeutics against cancer by reprogramming the tolerogenic tumor microenvironment, including regulatory T-cells, thrombocytes and unfolded protein response. My work is supported by the National Institutes of Health, including a program project grant from the National Cancer Institute and four RO1s for which I am principal investigator.
I am also widely published in scientific journals on the topics of immune tolerance, cancer immunology and chaperone biology, and serve as an elected member of such professional organizations as the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP).
研究兴趣
论文共 294 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature Communicationsno. 1 (2024): 338-338
Cancer Immunology, Immunotherapyno. 3 (2024): 52-52
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 1 (2024)
Nathan Denlinger, No-Joon Song,Xiaoli Zhang,Hyeongseon Jeon,Chelsea Peterson,Yi Wang,Kelsi Reynolds, Robert Bolz, Jessica Miao,Chunhua Song,Dayong Wu,Wing Keung Chan,
Blood advances (2024)
Dixita M. Patel, Ruba Mateen, Noor Qaddour, Alessandra Carrillo,Claire Verschraegen,Yuanquan Yang,Zihai Li,Debasish Sundi,Amir Mortazavi,Katharine A. Collier, Toyonori Tsuzuki
CANCERSno. 2 (2024): 335
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
引用0浏览0引用
0
0
Natureno. 7970 (2023): 624-631
Jacob Kaufman,Dwight Hall Owen, Regan Michelle Memmott,Gregory Alan Otterson,Kai He,Carolyn J. Presley,Daniel Spakowicz,Peter G. Shields,Xiaoli Zhang, Theresa A. Boyle,W. Douglas Cress, Kris Wood,
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): 2626-2626
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn