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We have recently shown that subpopulations of natural and/or inducible regulatory T (Treg) cells potently inhibit atherosclerotic lesion development and inflammation. We hypothesise that Treg cells and similarly, B cell type regulatory populations, have a broader role in the control of vascular inflammation and may significantly alter atherosclerosis or AAA development and progression. We will study in detail the mechanisms leading to recruitment of the different T and B cell subsets into the injured vessel wall and the pathways by which they modulate vascular inflammation. We will also develop novel immuno-modulatory and vaccination-based strategies to promote protective immune responses in atherosclerosis and AAA, with the aim to radically change the management and treatment of these common and serious vascular diseases.
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Archives of Cardiovascular Diseases Supplementsno. 1 (2023): 115-115
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NATURE COMMUNICATIONSno. 1 (2022)
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ATHEROSCLEROSIS: TREATMENT AND PREVENTION (2013)
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