The Zhao Wang lab focuses on pathological cardiac remodeling due to cardiac hypertrophy, heart failure, cancer treatment, myocardial infarction, senescence and diabetes. We use approaches that span biomedical disciplines, integrating genetics in lab models, tissue culture, imaging and multi-omics. Our work has yielded exciting insights about the roles of myocardial metabolism, the unfolded protein response, the integrated stress response, translation regulation and adipokines.