Dr Zdenko Herceg has international reputation as the leader in the application of epigenetic/epigenomic analyses to mechanistic and profiling studies of carcinogenesis and discovery of biomarkers of environmental exposures and cancer risk. An important emphasis is placed on understanding the origins and causes of human cancer by investigating epigenetic changes associated with environmental risk exposures. He has developed and co-ordinated a number of multidisciplinary projects involving epigenomics and mechanistic studies involving international case-control and population-based studies. These include major initiatives for international interdisciplinary collaborations (funded by major International and French funding agencies including EU, NIH/NCI, Gates Foundation, INCA-France, ARC, WCRF-UK, New Frontier Research Fund, Canada).