基本信息
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职业迁徙
个人简介
Research interests:
Our laboratory is dedicated to explore the molecular basis of hematopoiesis, hematopoietic malignancies and liver metabolism-associated diseases. Major researches include:
1. Megakaryopoiesis and pathogenesis of Myeloproliferative Neoplasms (MPNs) and Acute Myeloid Leukemia (AML): We investigate signal transduction, transcriptional, and epigenetic regulation of megakaryopoiesis; explore the molecular basis of MPNs (Primary Myelofibrosis) for target therapy; identify key regulators controlling AML cell proliferation, survival, and malignancy as well as novel biomarkers.
2. Pathogenesis of liver metabolism-associated diseases: We dissect molecular mechanism underlying the progressive evolution of Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH), Cirrhosis to Hepatocellular Carcinoma; unveil the decisive factors determining Hepatic Ischemia/Reperfusion Injury; particularly focus the function of innate immunity and ubiquitination/deubiquitination that regulate metabolism and ultimately contributes to these diseases .
Our laboratory is dedicated to explore the molecular basis of hematopoiesis, hematopoietic malignancies and liver metabolism-associated diseases. Major researches include:
1. Megakaryopoiesis and pathogenesis of Myeloproliferative Neoplasms (MPNs) and Acute Myeloid Leukemia (AML): We investigate signal transduction, transcriptional, and epigenetic regulation of megakaryopoiesis; explore the molecular basis of MPNs (Primary Myelofibrosis) for target therapy; identify key regulators controlling AML cell proliferation, survival, and malignancy as well as novel biomarkers.
2. Pathogenesis of liver metabolism-associated diseases: We dissect molecular mechanism underlying the progressive evolution of Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH), Cirrhosis to Hepatocellular Carcinoma; unveil the decisive factors determining Hepatic Ischemia/Reperfusion Injury; particularly focus the function of innate immunity and ubiquitination/deubiquitination that regulate metabolism and ultimately contributes to these diseases .
研究兴趣
论文共 138 篇作者统计合作学者相似作者
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Clinical and translational medicineno. 10 (2023): n/a-n/a
Research Square (Research Square) (2023)
British Journal of Pharmacologyno. 6 (2022): 701-720
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Journal of hepatologyno. 3 (2022): 627-642
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