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Our lab studies tissue dynamics in living embryo and cultured tissue. We are interested in two particular aspects, how cell mechanics that evolve over time and in space emerge as large-scale tissue dynamics (as an intrinsic force), and how cell mechanics arises from tissue dynamics and feedback to cellular and molecular function (as an extrinsic force). To study the mechanical interactions between cells within a tissue, we detect and extract the mechanical signatures (e.g., cell-cell adhesion, cytoskeleton, and mechanical forces) from a tissue with an interdisciplinary approach that combines imaging, quantitative analysis, gene manipulation, biophysical manipulation tools (e.g., laser ablation), and biophysical modeling. The major scientific topics we have been asking lie in 2 areas: Mechanical role of apoptosis (a.k.a. apoptotic force) within a tissue, and 3D cell shape changes during collective cell migration.
Our lab studies tissue dynamics in living embryo and cultured tissue. We are interested in two particular aspects, how cell mechanics that evolve over time and in space emerge as large-scale tissue dynamics (as an intrinsic force), and how cell mechanics arises from tissue dynamics and feedback to cellular and molecular function (as an extrinsic force). To study the mechanical interactions between cells within a tissue, we detect and extract the mechanical signatures (e.g., cell-cell adhesion, cytoskeleton, and mechanical forces) from a tissue with an interdisciplinary approach that combines imaging, quantitative analysis, gene manipulation, biophysical manipulation tools (e.g., laser ablation), and biophysical modeling. The major scientific topics we have been asking lie in 2 areas: Mechanical role of apoptosis (a.k.a. apoptotic force) within a tissue, and 3D cell shape changes during collective cell migration.
研究兴趣
论文共 68 篇作者统计合作学者相似作者
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Kun-Yang Lin,Gujar Mahekta, Jiaen Lin, Wei Yung Ding,Jiawen Huang,Yang Gao,Ye Sing Tan,Xiang Teng, Siok Lan Christine Low, Pakorn Kanchanawong,Yusuke Toyama,Hongyan Wang
biorxiv(2024)
Current biology : CBno. 22 (2023): R1205-R1207
Mahekta R Gujar,Yang Gao,Xiang Teng, Wei Ding, Jiaen Lin, Yan Tan,Liang Yuh Chew,Yusuke Toyama,Hongyan Wang
EMBO Reportsno. 9 (2023)
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Developmental cellno. 19 (2023): 1933-1949.e5
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