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Our laboratory focuses on cancer and viral chemotherapy. We are studying the functional roles and properties of virus-specific proteins in order to design selective antiviral compounds. Some anti-HIV drugs have selective action against mitochondrial DNA synthesis that could lead to toxicity. This observation offered the opportunity to develop new antiviral drugs without such side effects and to examine the role of mitochondrial DNA synthesis in nuclear DNA synthesis. A new class of biological active nucleoside analogs, L(-)nucleosides were discovered. Drug resistance is a critical issue in cancer chemotherapy.
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CANCER RESEARCHno. 7 (2023): 3078-3078
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Bo Wen, Xiaoyu Feng,Lulu Zhang,Li Li, Yumin Xia,Weifeng Yang,Yung‐Chi Cheng,Tariq Mahmood, Yong Ma,Chunyan Jiang,Cheng Lü,Yong Tan
Authorea (Authorea) (2023)
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