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Proteomics allow the large-scale identification of proteins in complex biological systems, but it often only produces static snapshots of proteomes that fail to describe and explain the dynamic nature of cellular behaviours. In contrast, modern cell imaging techniques allow the quantitative analysis of the spatial and temporal distribution of biomolecules in living cells, but only a relatively small number of proteins can be studied in one experiment. Our lab strives to bring together these two powerful methodologies to tackle fundamental biological questions. To this end, we perform quantitative mass spectrometry to measure the flux of a large number of proteins through subcellular spaces and to track the proteomic changes within cellular complexes through time. In parallel, we record these dynamic cellular behaviours in live cells using time-lapse fluorescence microscopy. From these two angles, we aim at building coherent pictures of intracellular events under different growth and metabolic conditions. This lab aims to apply this dual approach to a range of topics, from basic cell biology to environmental sciences.
Proteomics allow the large-scale identification of proteins in complex biological systems, but it often only produces static snapshots of proteomes that fail to describe and explain the dynamic nature of cellular behaviours. In contrast, modern cell imaging techniques allow the quantitative analysis of the spatial and temporal distribution of biomolecules in living cells, but only a relatively small number of proteins can be studied in one experiment. Our lab strives to bring together these two powerful methodologies to tackle fundamental biological questions. To this end, we perform quantitative mass spectrometry to measure the flux of a large number of proteins through subcellular spaces and to track the proteomic changes within cellular complexes through time. In parallel, we record these dynamic cellular behaviours in live cells using time-lapse fluorescence microscopy. From these two angles, we aim at building coherent pictures of intracellular events under different growth and metabolic conditions. This lab aims to apply this dual approach to a range of topics, from basic cell biology to environmental sciences.
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LASER & PHOTONICS REVIEWS (2024)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 29 (2023)
Miao Dong, Shu Hin Kwok,Joseph L. Humble,Yimin Liang,Sze Wing Tang, Kin Hung Tang,Man Kit Tse,Josh Haipeng Lei,Rajkumar Ramalingam,Mohamad Koohi-Moghadam,Doris Wai Ting Au,Hongyan Sun,
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