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The research in the Section on Molecular Morphogenesis focuses on the understanding of the molecular mechanism by which thyroid hormone (TH) regulates postembryonic development in vertebrates. The main model is the metamorphosis in Xenopus laevis and tropicalis, two highly related anuran species. Amphibian metamorphosis resembles the perinatal period in mammals when plasma TH concentrations are also high. The control of this developmental process by TH (Fig. 1) offers a unique paradigm in which to study genes that are important for postembryonic organ development. During metamorphosis, different organs undergo vastly different changes. Some, like the tail, undergoes complete resorption, while others, such as the limb, are developed de novo. Most of the larval organs persist through metamorphosis but are dramatically remodeled to function in a frog. For example, tadpole intestine in Xenopus laevis is a simple tubular structure consisting of primarily a single layer of larval epithelial cells. During metamorphosis, it is transformed into a multiply folded adult epithelium with elaborate connective tissue and muscles through specific cell death and selective cell proliferation and differentiation.
The research in the Section on Molecular Morphogenesis focuses on the understanding of the molecular mechanism by which thyroid hormone (TH) regulates postembryonic development in vertebrates. The main model is the metamorphosis in Xenopus laevis and tropicalis, two highly related anuran species. Amphibian metamorphosis resembles the perinatal period in mammals when plasma TH concentrations are also high. The control of this developmental process by TH (Fig. 1) offers a unique paradigm in which to study genes that are important for postembryonic organ development. During metamorphosis, different organs undergo vastly different changes. Some, like the tail, undergoes complete resorption, while others, such as the limb, are developed de novo. Most of the larval organs persist through metamorphosis but are dramatically remodeled to function in a frog. For example, tadpole intestine in Xenopus laevis is a simple tubular structure consisting of primarily a single layer of larval epithelial cells. During metamorphosis, it is transformed into a multiply folded adult epithelium with elaborate connective tissue and muscles through specific cell death and selective cell proliferation and differentiation.
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