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Yu-li Wang’s research group has focused their effort on cellular mechanical activities that serve as the foundation for a wide range of health-related applications from tissue engineering to cancer treatment. Specifically, they are interested in how cells use mechanical means to probe the environment, respond to physical stimuli, communicate with each other, and propel the migration. Their recent studies have demonstrated the sensitivity of adhesive cells to the dimensionality of the environment and to their own shape and migration state. They have also discovered that cells use thin extensions at the front for probing and steering the migration, and use centrosomes to position the tail for retraction. They are also studying how a group of cells respond collectively to mechanical forces and undergo coordinated migration. They are deploying the knowledge of cell-material interactions for developing a new generation of composite materials for medical devices and artificial organs.
Research Interests: mechanical interactions between cells and the environment; mechanisms of cell migration and division; cellular mechanical activities; synthetic polymeric materials for cell, tissue, and organ engineering
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Jui-Chien Lien,Yu-Li Wang
Biophysical journalno. 15 (2023): 3146-3158
Y.L. Wang, Y.-C. Lin
Jui-Chien Lien,Yu-Li Wang
Research Square (Research Square) (2021)
David Li,Yu-li Wang
Principles of Tissue Engineeringpp.237-256, (2020)
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