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职业迁徙
个人简介
My research work focuses on translational aspects of type 2 diabetes and other aging-related metabolic diseases, from identification and validation of novel drug targets, development of high throughput screening assays, to preclinical testing of potential therapeutic compounds in animal models. Our work has recently identified a critical missing link between mitochondrial dysfunction in aging and the onset aging-related metabolic diseases, including diabetes, heart failure, stroke, and Alzheimer’s diseases. Using genome-wide synthetic lethal screening, we have also identified a family of novel regulators of phospholipid trafficking between ER and mitochondria. We are currently characterizing their function in regulating the onset of aging-related diseases.
Related Diseases: Mitochondrial dysfunction, cardiolipin remodeling, aging, metabolic diseases.
Techniques: Molecular cloning, confocal imaging analysis of mitochondrial dynamics, enzymatic assays, signal transduction, mitochondrial respiration, transgenic and knockout mice, metabolic phenotyping, echocardiography, glucose tolerance, insulin tolerance and animal surgery
研究兴趣
论文共 58 篇作者统计合作学者相似作者
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Free Radical Biology and Medicine (2024): 129-136
CELL REPORTSno. 11 (2023): 113214-113214
Molecular metabolism (2022): 101536-101536
Social Science Research Network (2021)
Dandan Jia,Jun Zhang, Jia Nie,John-Paul Andersen, Samantha Rendon, Yue Zheng,Xueling Liu, Zhenjun Tian,Yuguang Shi
Journal of Clinical Investigationno. 24 (2021)
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