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个人简介
Why do we need sleep? How are sleep states initiated, maintained, and ended? How does sleep impact normal brain functions? What roles does sleep play in neuropsychiatric disorders? The goal of our research is to understand the circuit, cellular, and molecular mechanisms underlying sleep regulation in both normal and diseased brains.
We use a multidisciplinary approach including electrophysiology, calcium imaging, optogenetics, chemogenetics, pharmacology, viral-based neural tracing, molecular biology, and mouse genetics to study the neurobiology of sleep. Currently, we aim to 1) dissect brain circuits that control sleep and wakefulness; 2) identify genes and signaling molecules that initiate and maintain sleep; 3) examine how sleep loss affects brain functions and animal behaviors, such as sensory perception, learning, and memory.
In collaboration with other faculty members at Columbia, we are also interested in understanding the relationship between sleep disruption and neurological/psychiatric disorders. Specifically, we focus on epilepsy and mood disorders. We aim to identify common neuropathological mechanisms underlying abnormal sleep and brain diseases.
We use a multidisciplinary approach including electrophysiology, calcium imaging, optogenetics, chemogenetics, pharmacology, viral-based neural tracing, molecular biology, and mouse genetics to study the neurobiology of sleep. Currently, we aim to 1) dissect brain circuits that control sleep and wakefulness; 2) identify genes and signaling molecules that initiate and maintain sleep; 3) examine how sleep loss affects brain functions and animal behaviors, such as sensory perception, learning, and memory.
In collaboration with other faculty members at Columbia, we are also interested in understanding the relationship between sleep disruption and neurological/psychiatric disorders. Specifically, we focus on epilepsy and mood disorders. We aim to identify common neuropathological mechanisms underlying abnormal sleep and brain diseases.
研究兴趣
论文共 28 篇作者统计合作学者相似作者
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SLEEPno. Supplement_1 (2023): A34-A34
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Gergely F. Turi, Xinyue Chen,Sasa Teng, Emily CY Lim,Carla Dias, Ruining Hu,Fenghua Zhen,Yueqing Peng
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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SLEEPno. Supplement_1 (2023): A20-A20
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Frontiers in cellular neuroscience (2023): 1175895-1175895
Bio-protocolno. 9 (2023): e4664-e4664
SLEEPno. Supplement_1 (2023): A33-A34
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Susanto Teng,Fenghua Zhen,Li Wang, Jose Canovas Schalchli,Jane Simko,Xinyue Chen,Hao Jin,Christopher D. Makinson,Yueqing Peng
NATURE COMMUNICATIONSno. 1 (2022): 4748
biorxiv(2021)
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