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Yue Wang’s research in the past two decades has focused on the identification and characterization of factors that determine the virulence of the fungal human pathogen Candida albicans. He has made a series of ground-breaking discoveries. His lab discovered that the pathogen uses a specific iron uptake mechanism to acquire this essential nutrient for survival and causing infection in the host. He also discovered a master regulator, called Hgc1, of the yeast-hyphae transition, a major virulence trait of C. albicans. His group then identified a number of effector molecules of Hgc1 and elucidated how these molecules coordinate to construct hyphae. One of his recent seminal findings is to uncover bacterial peptidoglycan in human blood as a potent activator of the yeast-hyphal transition. He found that peptidoglycan in the blood enters C. albicans cells to activate the sole adenylate cyclase to turn on the expression of hyphae-specific genes including HGC1. His findings have significantly advanced our understanding of molecular mechanisms that govern the virulence and pathogenicity of this major microbial pathogen and identified potential targets for the development of diagnostic and therapeutic tools for combating this terrible human disease. For his multiple ground breaking discoveries in the study of the virulence factors and basic biology of the human fungal pathogen C. albicans, Dr Wang was awarded the President’s Science Award 2012.
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MBIOno. 6 (2023): e0268823-e0268823
Cureusno. 8 (2023): e43848-e43848
Advanced Drug Delivery Reviews (2023): 114896-114896
Frontiers in molecular biosciences (2023): 1182512
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