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The overall object of the research of Dr. Zhai is to elucidate the mechanisms of inflammatory immune activation and resolution in Liver ischemia/reperfusion (IR) injury. His work in KC/macrophage subsets in IR livers revealed that liver inflammatory immune activation is associated with not only increases/activations of infiltrating macrophages (iMØs), but also a drastic depletion of resident KCs (KCs). The opposite, i.e., contraction of iMØs and recovery of KCs, is associated with the resolution of liver inflammation. Additionally, M1 polarization is evident in the activation stage, and M2 polarization in the resolution stage of liver immune response in both liver macrophage subsets. Dr. Zhai hypothesizes that IR triggers KC necroptosis which constitutes a key mechanism of liver inflammatory immune activation and functions in synergy with the infiltration and activation of iMØs. Additionally, KCs execute the homeostatic function in liver IRI by phagocytosis of apoptotic/necrotic cells, which regulates KC innate immune activation and promotes their polarization towards immune regulatory/reparative type. Results will potentially provide novel rationale to design appropriate cell-targeted therapies to ameliorate liver IRI.
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Papers共 285 篇Author StatisticsCo-AuthorSimilar Experts
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PLANT BIOLOGYno. 1 (2024): 126-139
arXiv (Cornell University) (2023)
Physical reviewno. 3 (2023)
PHYSICAL REVIEW LETTERSno. 3 (2023)
HAL (Le Centre pour la Communication Scientifique Directe) (2023)
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Hanwen Zhang, Ming Ni, Han Wang,Jing Zhang, Dan Jin,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski,Wei Li,Xuehao Wang,Yuan Zhai
JCI Insightno. 1 (2023)
PHYSICAL REVIEW Dno. 11 (2023)
JCI insightno. 1 (2023)
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