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The questions we would like to address in the next few years include how cortical and medullary microenvironments in the thymus positively and negatively select functionally potent and self-tolerant T cell repertoire. We would also like to study the mechanisms involved in how diverse microenvironments are formed in the thymus to shape T cell repertoire and how multiple thymic microenvironments sequentially guide to position developing T cells for their repertoire formation.
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crossref(2024)
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